Would you be interested in participating in a clinical research study for pain associated with endometriosis?

We invite you to find out if you may be able to take part in a study for women who experience moderate-to-severe pain associated with endometriosis. Eligible participants will receive all study-related care, investigational medication, and non-hormonal birth control supplies (as applicable) at no cost. In addition, eligible participants may receive compensation for time and travel. No health insurance is required.

The ELARIS EM-COC study is evaluating the safety and effectiveness of an oral investigational medication when taken together with a combined oral contraceptive that contains estrogen and progesterone, in premenopausal women that are experiencing endometriosis pain.

You may qualify for the ELARIS EM-COC study if you:

  • Are a premenopausal woman between the ages of 18 and 49
  • Have had a surgical diagnosis of endometriosis
  • Have moderate-to-severe pain from endometriosis
  • Are not pregnant, actively trying to get pregnant or breastfeeding
  • Do not have osteoporosis (thinning, weak bones) or any other bone disease
Volunteers who take part in the study may receive compensation for time and travel.
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In this study, researchers will be evaluating the safety and effectiveness of an oral investigational medication when taken with an oral contraceptive, in premenopausal women with moderate-to-severe pain due to endometriosis. The combined oral contraceptive contains both estrogen and progesterone medication and has been approved by the US FDA as a method of contraception. The investigational medication has been FDA approved for moderate-to-severe pain associated with endometriosis. However, the investigational medication is not approved to be used together with a combined oral contraceptive, therefore the use of the investigational medication combined with the oral contraceptive is investigational (experimental) for the purposes of this study.

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What happens if I sign up?We will match you to a clinical research center location in your area that needs volunteers for the study or notify you when one nearby becomes available. A study staff member from that research center will then contact you and you may have the opportunity to participate if qualified.


If you think you might like to participate in the ELARIS EM-COC study or would like more information, please enter your information below so we can see if you may qualify and can contact you about the study. Keep in mind that participation is entirely voluntary. If you do decide to take part in a study, you may change your mind about participating at any time.

About the ELARIS EM-COC Study

The ELARIS EM-COC study will enroll about 800 women with moderate-to-severe pain associated with endometriosis at approximately 160 research centers in the United States and Puerto Rico.

Eligible participants will receive all study-related care, investigational medication, and non-hormonal birth control supplies from an experienced study doctor and medical staff at no cost.

The study will include approximately 12 visits to a research center in your location over approximately 21 to 33 months.

Volunteers who qualify to take part in the study may receive compensation for time and travel.

Who can take part in the ELARIS EM-COC study?

You may be able to take part in the study if you:

  • Are a premenopausal woman between the ages of 18 and 49
  • Have had a surgical diagnosis of endometriosis
  • Have moderate-to-severe pain from endometriosis
  • Are not pregnant, actively trying to get pregnant or breastfeeding
  • Do not have osteoporosis (thinning, weak bones) or any other bone disease

In this study, researchers with be evaluating the safety and effectiveness of an oral investigational medication when taken with an oral contraceptive, in premenopausal women with moderate-to-severe pain due to endometriosis.

Frequently Asked Questions

What is a clinical research study?

A clinical research study (also called a clinical trial) is a medical research study that helps to answer important questions about an investigational medication – these may include how well an investigational medication works for a certain condition. All medications must be tested in clinical research studies before they can be approved and prescribed to patients.

The purpose of the ELARIS EM-COC study is to look at the safety and effectiveness of the oral investigational medication when taken together with a combined oral contraceptive that contains estrogen and progesterone, in women with moderate-to-severe pain due to endometriosis.

This study is being conducted at approximately 160 research centers in the United States and Puerto Rico. Approximately 800 subjects with moderate-to-severe endometriosis-associated pain will participate in this study.

If you agree to be in this research study, the study doctor will determine if you are eligible. You may also be asked about your medical history, undergo medical tests (including physical examinations, blood, and urine tests, etc.), and complete questionnaires as part of your study participation. Please note you will also be asked to undergo dual energy X-ray absorptiometry (DXA) scans, as a means of measuring your bone mineral density throughout the study.

Eligible participants will be randomly assigned (like flipping a coin) to receive either the oral investigational medication or placebo in addition to a combined oral contraceptive or placebo once a day for 3 months. To prevent opinions about the investigational medication from affecting the study results, the study is designed so that participants, the study doctor, and the study staff will not know which study treatment arm you are assigned to. However, in the event of an emergency, this information can be provided. During this 3-month period, you will be able to take additional study allowed pain medication prescribed by your study doctor if necessary, for your endometriosis pain. This is called “pain rescue medication”. After this initial 3-month period, all subjects will receive the active oral investigational medication (no placebo) plus the combined oral contraceptive. Both will be taken once a day.

The combined oral contraceptive contains both estrogen and progesterone medication and has been approved by the US FDA as a method of contraception. The investigational medication has been FDA approved for moderate-to-severe pain associated with endometriosis. However, the investigational medication is not approved to be used together with a combined oral contraceptive, therefore the use of the investigational medication combined with the oral contraceptive is investigational (experimental) for the purposes of this study.

In total, your participation in this study will last approximately 21 to 33 months and include approximately 12 study visits to the research center and approximately 10 phone visits.

Volunteers who qualify to take part in the study may receive compensation for time and travel. Please discuss this with the study team when they contact you.

There is no cost to participate in the ELARIS EM-COC study.

If you decide to take part:

  • You will be monitored closely by an experienced study doctor and medical staff.
  • You will receive all study-related care, investigational medication, and non-hormonal birth control supplies at no cost.

Neither you nor your insurance company will have to pay for the investigational medication (or placebo) or procedures that are done only for the study. You or your insurance company will be responsible for the costs of your regular medical care. Regular medical care costs are the costs for medications, treatments, procedures, and testing that you would have had if you were not in the study.

The research center team will be able to explain more about what the ELARIS EM-COC study will involve, and it is up to you to decide if you want to take part. Participation in this study is voluntary. Whether or not you decide to participate in this study will not affect your current or future relationships with your doctors. If you decide to participate, you are free to withdraw at any time without affecting those relationships.

We try to match you to a research center within a close travel distance from your home. If we are not conducting the study in your area currently, with your permission, we will keep you in our database and reach out once a research center in your area becomes available. If, at any time, you decided you no longer want your information stored, you can let us know and we will delete your details (called "opt out").

About Endometriosis

Endometriosis is an often-painful condition in which tissue that normally lines the uterus grows outside of the uterus. Typically, endometriosis will involve the ovaries, fallopian tubes, and the tissue of the pelvis, although in some rare cases, can spread beyond the pelvic organs to other areas of the body.1

Endometriosis is estimated to affect 1 in every 10 women during their reproductive years.2 This accounts for approximately 176 million women, worldwide.

Although women may experience endometriosis differently, common symptoms may be:1

  • Pain during menstruation (periods)
  • Pain between periods
  • Painful intercourse
  • Painful bowel movements
  • Depression and fatigue
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The ELARIS EM-COC study is evaluating the safety and effectiveness of an oral investigational medication when taken together with a combined oral contraceptive that contains an estrogen and a progesterone, in premenopausal women with endometriosis-associated pain.